Ethambutol 275, Isoniazid 75, Pyrazinamide 400, Rifampin 150 is a fixed dose combination tablet and used with other cancer medicines for anti-TB chemotherapeutic regimens. It is a pinkish-violet coloured, biconvex, caplet shaped, film coated tablet and plain on both sides.
The medicine belongs to the class of antituberculars, ethylenediamines, hydrazines, isonicotinic acids; pyrazines, rifamycin.
The combo is used for antibacterial therapy.
Rifampin 150: It is a complex macrocyclic antibiotic that inhibits ribonucleic acid synthesis in microbial pathogens and it is a semisynthetic derivative of rifamycin.
It has bacterial action and a potent sterilizing effect against tubercle bacilli in both cellular and extracellular locations.
Isoniazid 75: It is a hydrazide of isonicotinic acid. It absorbs and diffuses into all the fluids and tissues. The half-life plasma is genetically determined and it is highly bactericidal against replicating tubercle bacilli.
Pyrazinamide 400: It is a white crystalline powder and pyrazine analog of nicotinamide.
It stays stable at room temperature and soluble in water.
Ethambutol 275: It is a synthetic congener of 1,2 –ethane diamine and used in the combination of anti-TB drugs to prevent or delay the resistant strains emergence.
The combination medicine is used in antibacterial therapy and intensive phase of treating tuberculosis caused by Mycobacterium tuberculosis in adults and children with more than 20 kg weight.
Use separate preparations of the ingredients if one of the ingredient is suggested to be reduced.
The medicine is taken on empty stomach to improve gastrointestinal tolerance.
It largely reduces the risk of developing neuropathy.
It inactivates bacteria enzyme (RNA polymerase) that has essential proteins and reproduces TB bacteria.
It prevents the multiplication and growth of tuberculous bacteria in the body.
Do not use the medicine if you have liver disease, an attack of gout, history of chills, fever, joint pains, and stiffness.
Take proper care of your eyes as the medicine may blur the vision.
The tablet may cause temporary discoloration of your teeth, sweat, urine, and tears.
Monitor the plasma concentration in your body and reduce the dosage of the medicine if you have renal impairment.
Talk to your doctor about the pros and cons of the medicine to avoid contradictions and complications.